ADAPTIVE EQTLS REVEAL THE EVOLUTIONARY IMPACTS OF PLEIOTROPY AND TISSUE-SPECIFICITY WHILE CONTRIBUTING TO HEALTH AND DISEASE

Adaptive eQTLs reveal the evolutionary impacts of pleiotropy and tissue-specificity while contributing to health and disease

Large numbers of expression quantitative Fan trait loci (eQTLs) have recently been identified in humans, and many of these regulatory variants have large allele frequency differences between populations.Here, we conducted genome-wide scans of selection to identify adaptive eQTLs (i.e., eQTLs with large population branch statistics).We then tested i

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